Study identifies possible connection to autism development

A study finds a potential link to the development of autism.

Numerous studies conducted in recent years have demonstrated a connection between our general health and the bacteria in our stomachs.

Our mood, stress management, and risk of developing autoimmune diseases like type 1 diabetes and rheumatoid arthritis can all be impacted by these gut microbes.

According to a recent study published in The Journal of Immunology, there may be a link between gut bacteria and autism.

The World Health Organization defines autism as a group of brain development disorders that impact social interaction and communication.

Individuals with autism also “frequently have co-occurring conditions, including epilepsy, depression, anxiety, and attention deficit hyperactivity disorder as well as challenging behaviors like difficulty sleeping and self-injury,” according to the World Health Organization. These people’s intellectual capacities vary from person to person.

According to the research, our mother’s microbiota may have a bigger impact on our development of autism than our own.

In a statement, lead researcher and PhD candidate John Lukens of the University of Virginia School of Medicine said, “The microbiome can shape the developing brain in multiple ways.”

“The microbiome plays a crucial role in determining how the immune system of the offspring will react to an infection, injury, or stress.”

A molecule produced by the immune system known as interleukin-17a, or IL-17a, may be a crucial component of this puzzle. This molecule aids in the fight against fungal infections and is known to be involved in conditions like rheumatoid arthritis, multiple sclerosis, and psoriasis. However, it also appears to have an impact on the prenatal development of the brain.

Scientists employed mice with various gut bacterial species to investigate this. Bacteria in one group triggered a robust immune response involving IL-17a, whereas bacteria in the other group did not.

When IL-17a was blocked in the infant mice, both groups behaved normally. However, the mice in the first group began to exhibit symptoms associated with autism, such as repeating specific actions, after the treatment ended and the mice grew naturally.

Later, the researchers transferred the gut bacteria that caused inflammation to the second group by giving them the first group’s feces through a fecal transplant. The second set of mice started acting like they had autism, as was to be expected.

Even though the study has only been done on mice, it does lay the groundwork for future investigations that may reveal how much the mother’s intestinal health influences the emergence of neurodevelopmental disorders.

“Identifying characteristics of the pregnant mother’s microbiome that correlate with autism risk would be the next big step in translating our work to humans,” Lukens stated. “I believe that the most crucial thing is to determine what kinds of tools can be used to safely and effectively modify the mother’s microbiome.”

According to Lukens, there are risks associated with blocking IL-17a, even though it may also be a means of preventing autism. He stated, “If you consider pregnancy, the body is essentially accepting foreign tissue, which is a baby.” “People tend to avoid tampering with the immune system during pregnancy because maintaining the health of the embryo requires a complex balance of immune regulation.”

He said that since IL-17a is only a small portion of a much larger picture, there are many other molecules to investigate.

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